Human Papillomavirus (HPV) Infected Epithelial Cells and FBLN1 ⁺ Fibroreticular Cells Govern the Immunogenic Tumor Microenvironment in HPV-Associated Oropharyngeal Squamous Cell Carcinoma

Our findings highlight the role of FBLN1+ FRCs in fostering immune activation within the TME of HPV-associated OPSCC. Enhanced antigen presentation and epithelial proliferation likely facilitate tumor-immune interactions, contributing to better clinical outcomes. This study advances the understanding of TME dynamics in OPSCC and may inform future therapeutic strategies.