Skin autofluorescence is associated with plasma levels of matrix metalloproteinases in subjects without overt atherosclerosis

In asymptomatic adults, higher skin autofluorescence is independently associated with circulating MMP-3, MMP-9, and TIMP-1, and with early carotid atherosclerosis markers. Findings support a link between tissue glycation and arterial matrix remodeling and suggest that skin autofluorescence plus MMP-9 may offer a practical, noninvasive approach for early vascular risk stratification.