Deaminative methylselenation of anlines with PhSO2SeCH3

Herein, we present a method for methylselenation of aryldiazonium salts that does not require metals or acids, achieved by directly transforming an amino group into a methylseleno group. This strategy is compatible with diverse anilines and facilitates rapid late-stage methylselenation of key pharmaceuticals and their derivatives, clearly demonstrating the utility of PhSO 2 SeCH 3 as a methylselenation reagent. Mild reaction conditions proceed efficiently at a 100 mmol scale, allowing double methylselenation of anilines and concise construction of aryl-SeCD 3 .