Synergistic Anticancer Activity of Dual-Molecule-Loaded Polymeric Films Based on Hyaluronic Acid Against Melanoma

Results highlight the potential of the obtained dual-molecule-loaded thin films based on hyaluronic acid as topical and safe antitumor therapy systems for local administration for the melanoma treatment. Moreover, due to the intrinsic properties of usnic acid and curcumin, and the biological activity of native hyaluronic acid, it is supposed that the obtained matrices possess the anti-inflammatory, antioxidant, antibacterial, and wound-healing activities, which are planned to be confirmed in further investigations.