Genetic Study of Carcinoma Breast in Northwest Rajasthan

We conducted a genetic study to investigate novel patterns in breast cancer within the population of Northwest Rajasthan.A total of 32 cases of modified radical mastectomy were randomly selected, with no exclusion based on age, occupation, or socioeconomic status.Genetic mapping was carried out to analyze mutations in P53, K-Ras, NAT2, and other genes associated with breast cancer susceptibility.We observed a consistent association of P53 and K-Ras mutations across all samples.Interestingly, NAT2 gene mutations were identified in 15 cases, and amplification of the KDMA6 gene was observed in one sample.Our findings underscore the significance of identifying NAT2 gene mutations in the Northwest Rajasthan population, especially given its more typical association with bladder cancer rather than breast cancer.This discovery provides new insights into the etiopathogenesis and potential genetic underpinnings of breast cancer in Rajasthan, India.