Activation of <scp>GPR35</scp> in the Anterior Cingulate Cortex Alleviates Neuropathic Pain and Depression‐Related Behavior

GPR35 is an essential regulator of NP and pain-related affective disturbances in the ACC. Its effects are mediated through the Nr4a1-dependent activation of the PI3K/AKT pathway and suppression of neuroinflammation. The pharmacological activation of GPR35 using L-Kyna provides analgesic and antidepressant benefits, highlighting GPR35 as a promising therapeutic target for NP and its emotional comorbidities.