Nitrosylcobalamin Selectively Targets Tumors via Cobalamin Uptake and Lysosomal Processing

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Authors

Joseph A. Bauer · Nitric Oxide Services (United States)

Annette M. Sysel · Bauer Research Foundation

Abstract

NO-Cbl utilizes tumor cell cobalamin transport and processing pathways to deliver nitric oxide selectively to cancer cells. These results, integrated with recent binding studies, validate NO-Cbl as a cobalamin-based targeted anticancer agent with efficacy in tumors expressing high levels of TCII and CD320.

Topics & Keywords

Porphyrin Metabolism and Disorders Folate and B Vitamins Research Vitamin C and Antioxidants Research

Publication Details

Published in: Frontiers in Bioscience-Elite

Volume 18, Issue 1, pp. 42272-42272

DOI: 10.31083/fbe42272

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Nitrosylcobalamin Selectively Targets Tumors via Cobalamin Uptake and Lysosomal Processing

Authors

Abstract

Topics & Keywords

Publication Details