Serum‐derived albumin as a cryoprotective agent for the long‐term storage of red blood cells: A preliminary examination

The cryoprotective effect of albumin appears dependent on rapid cooling and ionic co-solutes, suggesting a mechanism rooted in colloid-ion interactions rather than direct inhibition of ice formation. The dependence on freeze rate and ionic environment suggests that multiple solution properties contribute to its efficacy. While further work is required to clarify underlying mechanisms, albumin-based methods may provide a basis for a simplified method of cryopreservation.