Defining AV2‐1 as a novel pharmacological probe to target human and rodent TRPV2

AV2-1 represents a novel pharmacological tool for probing TRPV2 function in immune cells, combining improved selectivity and potency with low toxicity. Its ability to activate human TRPV2 and elicit physiologically relevant Ca²⁺ signals highlights its potential for advancing TRPV2 research and for therapeutic exploration in immune modulation and disease contexts.