COL11A1 Inhibits Ferroptosis in Pancreatic Cancer by Regulating AKT/Beclin 1 Dependent Autophagy

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Authors

Hui Wang · Tianjin Institute of Pharmaceutical Research (China)

Shuang Zhi · Tianjin Institute of Pharmaceutical Research (China)

Zibo Yang · Tianjin Institute of Pharmaceutical Research (China)

Na Gu · Tianjin Institute of Pharmaceutical Research (China)

Linlin Dai · Tianjin Institute of Pharmaceutical Research (China)

Jun Cai · Tianjin Institute of Pharmaceutical Research (China)

Abstract

The study demonstrated that COL11A1 exerts its oncogenic effects by suppressing autophagy via the AKT/Beclin 1 pathway, consequently inhibiting ferroptosis in pancreatic cancer cells. These findings reveal a novel molecular mechanism through which COL11A1 promotes tumor progression and provide a potential therapeutic target for pancreatic cancer treatment.

Topics & Keywords

Ferroptosis and cancer prognosis Immune cells in cancer Cancer Mechanisms and Therapy

UN Sustainable Development Goals

No poverty

Publication Details

Published in: Frontiers in Bioscience-Landmark

Volume 31, Issue 3, pp. 49200-49200

DOI: 10.31083/fbl49200

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