Lem3, a phospholipid flippase subunit, influences <i>Candida albicans</i> pathogenicity through maintenance of plasma membrane asymmetry

Plasma membrane lipid composition, maintained by lipid translocators, is a key determinant of virulence in pathogenic fungi. Here, we demonstrate that Lem3, the regulatory subunit of the flippase complex, by regulating the asymmetric distribution of phospholipids, impacts the expression of virulence traits and modulates drug resistance in <i>Candida albicans</i>. These findings highlight how diverse cellular processes are interconnected through flippase-mediated lipid homeostasis. With the alarming rise in fungal infections and antifungal resistance, targeting lipid translocators such as Lem3 offers a promising avenue for the development of novel therapeutic targets.