Early and Prolonged Cortical Electrical Stimulation Preserves Motor Functions and Nigrostriatal Dopaminergic Neurons in the MitoPark Model of Parkinson’s Disease

These findings demonstrate that early and sustained CES intervention mitigates motor deficits and enhances dopaminergic neuron survival in the MitoPark PD model. The results provide compelling preclinical evidence supporting CES as a potential adjunctive neuromodulatory therapy for Parkinson's disease.