Efficacy of Glucagon‐Like Peptide‐1 Receptor Agonists for Psychological Well‐Being and Depressive Symptoms: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials

GLP-1RA treatment was associated with modest improvements in psychological well-being but not depressive symptoms. These findings should be interpreted cautiously and suggest that any observed psychological benefits are likely indirect, potentially reflecting improvements in metabolic status or general health, rather than direct mood-improving effects.