A potential mechanism and strategy for accelerating recovery of neurocognitive function after general anaesthesia through store‐operated Orai1 channels

20260 citationsJournal Article

Authors

Ryota Watanabe · Tokyo Metropolitan University

Kotaro Hori · Tokyo Metropolitan University

Yukimi Kira · Osaka City University

Shogo Tsujikawa · Tokyo Metropolitan University

Hideki Hino · Tokyo Metropolitan University

Tadashi MATSUURA · Tokyo Metropolitan University

Takashi Mori ·

Abstract

Store-operated Orai1 channels in inhibitory neurons could play a critical role in delayed recovery following general anaesthesia, potentially by regulating action potential generation. Pharmacological inhibition of the channels may prevent perioperative neurocognitive disorder.

Topics & Keywords

Ion Channels and Receptors Ion channel regulation and function Sleep and Wakefulness Research

Publication Details

Published in: British Journal of Pharmacology

DOI: 10.1111/bph.70438

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A potential mechanism and strategy for accelerating recovery of neurocognitive function after general anaesthesia through store‐operated Orai1 channels

Authors

Abstract

Topics & Keywords

Publication Details