Effect of an educational intervention on knowledge and attitude of antimicrobial resistance among school children in Nay Pyi Taw union territory: a quasi-experimental study

Background: Antimicrobial resistance (AMR) is a global threat to health and human development by interrupting the efforts and investments of countries to effectively combat the infectious diseases. The overuse and misuse of antimicrobial agents has been recognized as the main cause of AMR. Children of today are antibiotic consumers and prescribers of tomorrow. Building foundational knowledge early shapes their future decisions regarding antibiotic use. Therefore, educational intervention programs targeting them can be effective and have a long-term impact. Methods: A quasi-experimental study was conducted among grade-10 students attending public schools during the academic year 2025-26 in Nay Pyi Taw Union Territory, Myanmar. This study consisted of a baseline assessment, the educational intervention using Power point slides, discussion, game and group activities and post-intervention assessment among students in the intervention group compared to a control group using the validated knowledge and attitude questionnaires adapted from the questionnaires of lesson plans, worksheets and activities of e-Bug. Results: A total of 300 students participated in the study. There was statistically significant change in students’ knowledge and attitude. The mean knowledge and attitude scores were increased in the intervention group compared to the control group. The mean difference in knowledge scores was 2.7 (95% CI=2.3 to 3.2) and the mean difference in attitude scores was 1.2 (95% CI=0.7 to 1.7). Conclusions: Educational intervention on knowledge and attitude of antimicrobial resistance among school children is an effective strategy to enhance our younger generation's responsible antibiotic use.