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Aim: To explore the applicability of the Quality-of-Life in Children with Chronic Gastroduodenal Pathology scale in assessing health-related quality of life in children, both before and after treatment and during recovery. Methods: A specialized questionnaire, the Quality-of-Life in Children with Chronic Gastroduodenal Pathology, was designed to assess the quality of life in children with chronic gastroduodenal pathology. The questionnaire incorporates a minimal number of questions, targeting the primary clinical symptoms of the condition. The efficacy of the questionnaire in evaluating health improvement tactics was assessed through standard clinical studies involving this patient population. Results: The Quality-of-Life in Children with Chronic Gastroduodenal Pathology questionnaire was validated for reliability and effectiveness. Using standard treatments for chronic inflammatory diseases, patients demonstrated an 18.5% higher quality of life compared to those with peptic ulcer disease. Incorporating rehabilitation techniques, such as enteral oxygen therapy, further enhanced quality of life, resulting in a 7.4% improvement (30.65% versus 23.27% at the start of treatment). Conclusion: Clinical research has confirmed the validity and utility of the Quality-of-Life in Children with Chronic Gastroduodenal Pathology questionnaire in outpatient settings for children with chronic gastroduodenal pathology. This tool enables family physicians to quickly and effectively assess the quality of life in pediatric patients, facilitating informed decisions regarding treatment and rehabilitation strategies. Keywords: child, gastrointestinal diseases, quality of life, questionnaire, treatment