Newfoundland Mutation <i>TMEM43</i> -p.S358L Causes Impaired Cardiac Energy Metabolism and Mitochondrial Function Through Altered Protein Interaction

We suggest differential interaction of mutant TMEM43 with proteins of mitochondria and endoplasmic reticulum influences endoplasmic reticulum-mitochondrial contact sites. <i>TMEM43</i>-p.S358L primarily contributes to changes in mitochondrial function affecting lipid homeostasis and energy supply.