FE(ACAC)₃-CATALYZED ONE-POT SYNTHESIS OF SUBSTITUTED QUINOXALINE DERIVATIVES

Objective: The study was to develop an efficient and practical method for the synthesis of substituted quinoxaline derivatives, which are known for their significant biological activities and structural versatility, and serve as important building blocks in organic synthesis. Methods: A series of substituted quinoxaline derivatives were synthesized through a one-pot cyclocondensation reaction between substituted phenyl diamines and phenacyl bromide. The reaction was catalyzed by Fe(acac)₃ and carried out at 60 °C for a duration of 50–80 min. Resuts: The reaction successfully afforded quinoxaline derivatives (3a–3m) in good to excellent yields ranging from 88–94%. The synthesized compounds exhibited high purity, demonstrating the efficiency of the developed protocol. Conclusion: The present methodology offers several practical advantages, including a simple one-pot procedure, facile isolation of products, high yields, and an efficient cascading cyclocondensation process. This approach provides an effective and reliable route for the synthesis of substituted quinoxaline derivatives.