New Life for an Old Target: Melanin Concentrating Hormone (MCH) R1 Antagonists for Obesity

For more than two decades, MCHR1 antagonists have been extensively investigated, but clinical progress has been hindered by toxicity and inadequate brain exposure. This Viewpoint highlights recent advances that have enabled the discovery of a novel MCHR1 antagonist with improved brain penetration and reduced toxicity, allowing it to advance into clinical trials.