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The Middle East and North Africa (MENA) region confronts a severe and escalating challenge to its resource security, rooted in the complex interdependencies of the Energy-Water-Food (EWF) nexus. This paper presents a comprehensive analysis of the long-term impacts of alternative policy pathways on EWF security and associated socio-economic outcomes. Utilizing a specifically designed Input-Output (IO) modelling framework incorporating flexible production functions and price-induced factor substitution, this study projects outcomes to the year 2050 for ten key MENA countries under five distinct scenarios: a Business-as-Usual (BAU) trajectory, three sector-specific scenarios focused on Energy (ESC), Water (WSC), and Food (FSC), and an integrated EWF Nexus-oriented Scenario (NSC). The analysis reveals that the BAU path, which extrapolates current policies and consumption patterns, leads to a precipitous decline in water and food security, rendering current development models fundamentally unsustainable.