Therapeutic potential of Lupinus albus L. kernel extracts against High Fructose diet induced Metabolic derangements in Wistar rats

Background: Metabolic syndrome is health concern across the globe, affecting vast population worldwide. According to the World Health Organization (WHO) reports 2010, the prevalence of metabolic syndrome is increasing globally due to the rising of obesity and physical inactivity. Objectives: In the present study, we evaluated Lupinus albus kernels for their potential in alleviating metabolic abnormalities associated with metabolic syndrome induced by High Fructose Diet. Materials and Methods: Hexane and ethyl acetate seeds extracts of L. albus kernels (HELA and EAELA) were screened for phytochemical constituents. Normoglycemic male albino Wistar rats were distributed into 6 groups with 6 in each. Fructose solution (10% w/v) administered p.o. for 8 weeks caused induction of Metabolic Disorder. The metabolic parameters were assessed and recorded before and after the administration of 200 mg/kg of extracts over 8 weeks. Results: Preliminary screening demonstrated the distribution of various phytoconstituents. EAELA showed a significant effect on physicochemical parameters like obesity. They also led to decreased expression of inflammatory mediators like IL-6, TGFβ, and TNF-α. Hematological parameters exhibited improvement whereas HbA1C expressed an increase in plasma insulin and HOMA IR revealed a decrease in insulin resistance when compared to disease control. Metabolic hormone levels also showed a positive change after administration. Antihyperlipidemic, antioxidant potential of the extracts was more proficient. Conclusion: The EAELA at 200 mg/kg displayed significant capacity in inhibiting the Metabolic Syndrome induced by High fructose diet.