Association of Circulating Vitamin D in Midlife With Increased Tau-PET Burden in Dementia-Free Adults

Low circulating vitamin D in later life has been associated with increased risk of cognitive impairment and clinical dementia. However, whether serum vitamin D in early midlife is associated with neuroimaging markers of preclinical dementia is unknown. We aimed to determine the association between early midlife serum vitamin D and subsequent tau and amyloid burden on brain-PET, in a cohort of dementia-free adults.