Retinoprotective Therapy Possibilities: A Cases Series

The article presents a cases series of retinoprotective therapy (RPT) using the water-soluble retinal polypeptide fractions (RPF). The 1st case: the nonproliferative diabetic retinopathy (DR) and cystoid macular edema patient after the 1st year of anti-VEGF therapy and retinal laser coagulation (RLС), which resulted in foveal retinal edema relief, a decrease in its intensity in the paraand perifovea, an increase of the best-corrected visual acuity (BCVA) from 0.03 up to 0.2, and the perimetric indices deviations (MD -12.86 dB; PSD 7.99 dB) relative to normal values. Three courses of RPT were administrated during the 2nd year of anti-VEGF therapy. BCVA increase (up to 0.3), MD normalization (-1.65 dB) and PSD decrease (4.96 dB) were noted 1month after the 3rd course of RPT. The 2nd case: the proliferative DR patient after subtotal 25-G vitrectomy, endo-RLC and silicone oil (SO) tamponade. MD (-8.04 dB) and PSD (4.61 dB) deviations were recorded 1-month after surgery. BCVA stabilization (0.3), MD improvement (-5.43 dB), PSD stabilization (4.61 dB) were noted 1-month after RPT. The 3rd case: the patient with low BCVA (0.08), MD (-14.15 dB) and PSD (7.86 dB) deviations 1-month after vitreous cavity revision with perfluorocarbon (PF) tamponade, endo-RLC and PF replacement with SO due to recurrent retinal detachment after the indirect non-open glob blunt injury. BCVA improved (0.2), MD decreased (-9.38 dB), and PSD stabilized (7.54 dB) one month after RPT. All patients noted improved quality of vision after RPT. The presented clinical cases, as well as many years of experience with the effective and safe use of RPF in patients with retinal pathology, provide grounds for recommending RPT after RLC and vitrectomy in patients with DR and retinal detachment.