Effectiveness of adjunctive low‐dose clobazam in adults with focal drug‐resistant epilepsy and incomplete response to cenobamate: A real‐world study

This study looked at adults with hard-to-treat focal epilepsy whose seizures were not fully controlled by cenobamate. Adding a low dose of clobazam to their existing treatment helped most patients reduce the number of seizures, with many achieving near-complete control. The combination was generally well tolerated, and most patients were able to continue therapy over 1 year. These findings suggest that strategically combining these two medicines can improve seizure control in patients who remain resistant to standard treatments.