UCHL1 Exacerbates Periodontitis by Coordinating Mitochondrial Dysfunction and Endoplasmic Reticulum Stress in Macrophages

20260 citationsJournal Article

Authors

Yun Yuan · Shanghai Jiao Tong University

Shengjia Ye · Shanghai Jiao Tong University

Hanxiao Xue · Shanghai Jiao Tong University

Xiayue Jin · Shanghai Jiao Tong University

Xueying Yang · Shanghai Jiao Tong University

Hongming Zhang · Shanghai Jiao Tong University

Hanyao Huang ·

Abstract

Our data suggest that UCHL1 may serve as a critical negative regulator for periodontitis treatment, and inhibition of UCHL1 is expected to improve the periodontal inflammatory microenvironment and promote alveolar bone regeneration.

Topics & Keywords

Oral microbiology and periodontitis research Bone Metabolism and Diseases Autophagy in Disease and Therapy

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Molecular Oral Microbiology

DOI: 10.1111/omi.70028

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