187eP GeneCa oncogenomic database: A decision support tool for precision oncology

Results: Consequently, the cytotoxic effect of the chalcone compound was observed in TPC-1 and 8505-C cells, while the cytotoxic effect for Nhty-Ori 3-1 was found to be quite low.The triple staining revealed that the chalcone compound induced apoptosis in TPC-1 and 8505-C cells. Conclusions:The results indicated that the synthesized and characterized 2-benzofuran-linked chalcone compound exhibited dose-and time-dependent cytotoxic activity on TPC-1 and 8505-C human thyroid cancer cells.Cytotoxicity was observed to a lesser extent in Nthy-Ori 3-1 cells than in cancer cells.Furthermore, the 2benzofuran-linked chalcone compound was found to induce apoptosis.Despite the promising findings of this in vitro study, it was concluded that the effect of in vivo conditions should be examined as a next step.