TBC1D23 drives lymphatic metastasis in pancreatic ductal adenocarcinoma by altering EGFR cell surface dynamics and signaling

These findings uncover TBC1D23 as a novel regulator of EGFR dynamics and a pivotal mediator of PDAC lymphatic metastasis. By delineating the TBC1D23/EGFR/VEGF-C signaling axis, this study not only identifies a promising biomarker for PDAC detection and prognosis but also highlights an actionable therapeutic target for intercepting metastatic progression.