IL-27-Ucp2-FoxO3 axis mediating the polarization of alternatively activated macrophages and ameliorating inflammatory pain

20260 citationsJournal Articlediamond Open Access

Authors

Yi Ma · First Affiliated Hospital Zhejiang University

Shuyuan Gan · First Affiliated Hospital Zhejiang University

Yueying Zheng · National Medical Products Administration

Xianhui Kang · First Affiliated Hospital Zhejiang University

Shengmei Zhu · National Medical Products Administration

Abstract

These findings reveal that the IL-27-Ucp2-FoxO3 axis regulates macrophage plasticity distinct from the canonical IL-4-mediated pathway through metabolic rewiring and facilitates alleviating Inflammatory pain.

Topics & Keywords

FOXO transcription factor regulation Immune cells in cancer Signaling Pathways in Disease

UN Sustainable Development Goals

Zero hunger

Publication Details

Published in: The Korean journal of pain

Volume 39, Issue 2, pp. 221-245

DOI: 10.3344/kjp.25307

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