Diagnostic Yield of Second-Line Functional Imaging After an Abnormal Coronary CTA: An Individual Patient-Data Meta-analysis

Second-line functional imaging after an abnormal CCTA enables identification of patients with anatomically severe CAD. In contrast, moderate stenoses (<70% DS) with FFR ≤0.80 do not consistently result in myocardial ischemia detectable by functional imaging tests. Substantial diagnostic accuracy differences were found between non-invasive diagnostic test which needs further investigation.