Neoadjuvant Chemotherapy Diminishes Ki-67 Overexpression and Persistent Overexpression is a Poor Prognostic Factor in Pancreatic Ductal Adenocarcinoma After Pancreatectomy

NAC diminishes Ki-67 overexpression, and persistent overexpression even after NAC is an independent poor prognostic factor of PDAC after pancreatectomy. The Ki-67 overexpression may mirror a high malignant state due to the low SMAD4 and high c-Myc expression.