Glaucomatous Remodeling of the Lamina Cribrosa: Association With Visual Field Progression

Glaucomatous remodeling of the LC is associated with VF progression in POAGs. The association between longitudinal structural remodeling and functional progression varies with age such that older individuals exhibit shallower remodeling (less posterior change in ALCSD and LCCI). Subjects with a higher IOP and thinner CCT showed greater posterior remodeling of the LC as glaucoma functionally progressed, indicating that these factors are mechanistically relevant to glaucomatous remodeling.