Andrographolide Attenuates Sepsis-Induced Acute Lung Injury via Peroxisome Proliferator-Activated Receptor Gamma in a Murine Cecal Ligation and Puncture Model

AGL's ability to upregulate PPARγ and enhance SOD and catalase activity further supports its mechanistic role in mitigating lung damage. The reversal of AGL protective effects by GW9662 confirms its PPARγ-dependent mechanism, highlighting its potential as a targeted protective treatment for sepsis-induced ALI.