Oligodendrocyte Precursor Cells Shape Retinogeniculate Refinement Via a CHD8-Dependent Phagocytic Pathway

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Authors

Siyue Wen · Sichuan University

Fen Guo · Sichuan University

Zhidan Li · Sichuan University

G. J. Huang · Sichuan University

Minghe Shen · Sichuan University

Xuelian He · Sichuan University

Abstract

Our results suggest that phagocytosis of excess synapses by OPCs around eye opening is a critical mechanism for visual development, driven by CHD8-mediated upregulation of phagocytosis-related genes. Dysregulation of this pathway is also linked to autism pathology.

Topics & Keywords

Retinal Development and Disorders Neurogenesis and neuroplasticity mechanisms Neuroscience and Neuropharmacology Research

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Investigative Ophthalmology & Visual Science

Volume 67, Issue 3, pp. 64-64

DOI: 10.1167/iovs.67.3.64

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