Functional Neuroimaging Biomarkers of Impaired Neurocognition After Proton Beam Radiotherapy for Brain Tumors in Pediatric Patients: A Prospective Trial

Compared with HCs, pediatric patients after PBRT displayed significant disruption in several RSNs, notably between SN and DMN critical in neurocognitive control. Dose-dependent neurocognition and QoL impairment warrant further investigation for mitigation.