First‐trimester pre‐eclampsia screening and adverse pregnancy outcomes beyond pre‐eclampsia

The risks for SGA/fetal growth restriction and PTB were significantly higher in those who screened positive at FMF first-trimester pre-eclampsia screening, even after adjusting for pre-eclampsia, and they may benefit from increased surveillance. Components of FMF-based first-trimester pre-eclampsia screening overlap substantially with uteroplacental great obstetrical syndromes, and help to identify a broader placental-risk phenotype. Future research may explore how this information could be further operationalized-through refinement of risk thresholds and incorporation of adjunctive strategies. Nevertheless, the lack of highly effective strategies to further stratify and prevent SGA/fetal growth restriction and spontaneous PTB remains a challenge.