Mitochondrial hyperoxidation contributes to warm ischemia-reperfusion injury in rat and pig livers

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Authors

Khanh T. Nguyen · Massachusetts General Hospital

O. Sila Ozgur · Massachusetts General Hospital

Rohil Jain · Massachusetts General Hospital

Christopher Taveras · Massachusetts General Hospital

Emmanuella O. Ajenu · Massachusetts General Hospital

Tyler Pugeda · Massachusetts General Hospital

Alona Muzikansky

Abstract

RRS assessment and guided treatment with methylene blue provide two lines of evidence indicating that mitochondrial hyperoxidation, specifically at complex III, is a critical mechanism underlying warm ischemia-reperfusion injury. This study demonstrates the potential of RRS for transplantation and broader applications.

Topics & Keywords

Organ Transplantation Techniques and Outcomes Spectroscopy Techniques in Biomedical and Chemical Research Mitochondrial Function and Pathology

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Communications Medicine

DOI: 10.1038/s43856-026-01551-4

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