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Acne scars are a common and highly psychosocially impactful sequela of acne vulgaris, affecting up to 95% of patients to varying degrees. Laser therapy has become a first-line tool in the management of these scars due to its ability to induce controlled dermal remodeling. Multiple laser modalities are currently available—including ablative lasers (such as CO₂ and Er:YAG), non-ablative fractional lasers, vascular lasers (PDL), long-pulsed Nd:YAG, picosecond lasers, and even hybrid platforms—eachwith distinct mechanisms of action and specific indications. This article provides a rigorous review of the most recent scientific evidence on the use of laser therapy for acne scars, comparing the clinical efficacy, safety profile, recovery time, cost, and level of evidence of all current technologies. A comparative table of the main laser technologies is presented, together with a practical treatment protocol based on international consensus and stratification by phototype, age, scar type (atrophic vs. hypertrophic; icepick, boxcar, and rolling subtypes), and severity. In addition, the limitations of current therapies, ongoing controversies (e.g., the concomitant use of laser therapy and isotretinoin), and emerging lines of research—such as the combination of lasers with other modalities (e.g., photodynamic therapy, radiofrequency microneedling, growthfactors) and novel ultrashort-pulse lasers—are critically discussed. The aim is to provide the specialist physician with an updated, evidence-based guide to optimize laser-based management of acne scars, maximizing clinical outcomes safely and in a personalized manner for each patient.