A Natural Pueraria─Based Conductive Cardiac Patch with Tree Frog Foot─Inspired Morphology for Myocardial Infarction Treatment

Following myocardial infarction, ventricular remodeling involves complex pathological cascades, and multiscale-designed cardiac patches hold promise for interventional treatment of myocardial infarction. This study, leveraging the multiple pharmacological activities of natural Pueraria polysaccharide, integrates nanotopological enhancement and micronano biomimetic techniques to develop a pharmacological-device integrated multifunctional conductive hydrogel cardiac patch (GPS@Au NPs). The patch is fabricated through dynamic Schiff base cross-linking to construct an oxidized Pueraria polysaccharide/gelatin composite network, with cysteamine-modified gold nanoparticles (Cys@Au NPs) introduced to form conductive pathways. Building on this foundation, 3D printing is further employed to construct a topological structure mimicking tree frog feet, achieving multidimensional synergistic optimization of mechanical properties, electrical signal conduction capabilities, and biological functions. This pathway realizes the transformation of traditional Chinese medicine polysaccharides from mere “drug molecules” to “functional interventional materials”. Its complex synergistic properties provide an innovative solution for myocardial repair, with the additional benefits of complete degradability and ecological sustainability, offering a pharmacological-device integrated therapeutic strategy for myocardial tissue engineering.