Regional Blood Flow Signatures of Opioidergic Modulation of Ketamine in Major Depressive Disorder: A Randomized Crossover Study

Accumulating evidence suggests that the opioid system may modulate ketamine’s rapid antidepressant effects. The objective of this study was to test whether opioid system modulation via naltrexone alters ketamine’s acute effects on regional cerebral blood flow (rCBF) in major depressive disorder (MDD), and whether these changes relate to symptom measures and map onto receptor density profiles.