Assessment of monocytes chemoattractant protein -1 as a biomarker in  females serum of hypertensive patients with and without Entamoeba histolytica

The current study deals with ninety (90) subjects as patients sixty (60)and thirty(30)as control.Samples were collected from suspected patients attended to Al-Sadr Medical City and Al-Furat Al-Awsat Teaching Hospital in Najaf province and also private laboratories. The serum were given from venous at (3-5)milliliter.Systolic and diastolic blood pressure were measured by Sphygmomanometer and lipid profile by AU480 Chemistry Analyzer, and biomarker Monocytes chemoattractant protein (MCP-1) was measured by ELISA technique. Women hypertensive patients were divided into sex sub groups according to types of hypertension (hypertensive only, hypertensive with hyperlipidemia and hypertensive with Entamoeba histolytica) ,also according to age, duration of disease, diagnosis , , body mass index , and according to family history .The current results revealed a significantly increase(p<0.0001) in monocytes chemoattractant protein (MCP-1) in women hypertension patients group in compare with control group ,biomarker revealed significant increase (p<0.0001) in age (50-59) years than other ages , in types of hypertensive sub groups also indicated significant increase(p<0.0001) in hypertension with hyperlipidemia in compare with another groups,in duration of disease(1-5) years showed a significant increase (p<0.0001) than(6-10) years , new diagnosis women patients were significant increase (p<0.0001) than treated ,obese women were highly significant (p<0.0001) than over weight and normal weight and familial hypertensive women were highly significant increase(p<0.0001) than nonfamilial hypertensive.The correlation of biomarker was showed significant positive correlation between all subgroups and both systolic and diastolic blood pressure . The present study concluded that Monocytes chemoattractant protein (MCP-1) biomarker considered as prognostic for prediction of hypertension in women.