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Introduction. The growing prevalence of lifestyle disorders has increased interest in cognitive health and mental well-being. Ayurveda offers a holistic approach through Medhya Rasayana – a class of herbal interventions aimed at enhancing intellect ( Dhi ), retention ( Dhrti ), and memory ( Smriti ). Aim. This article explores the classical Ayurvedic concept of nootropic agents, detailing their physiological basis in relation to Dosha balance and mind-body functions. Materials and methods. A range of herbs such as Shankhapushpi (Convolvulus pluricaulis), Brahmi (Bacopa monnieri), Jatamansi (Nardostachys jatamansi), Mandukaparni (Centella asciatica), Guduchi (Tinospora cordifolia), Ashwagandha (Withania somnifera), Amalaki (Phyllanthus emblica), Sarpagandha (Rauvolfia serpentina), Hareetaki (Terminalia chebula), Shatavari (Asparagus racemosus), Vacha (Acorus calamus), and Jyotishmati (Celastrus paniculatus) added with importance of ghrita (medicated ghee) as suitable dosage are discussed with classical references and modern pharmacological evidence highlighting their neuroprotective, adaptogenic, and memory-enhancing effects. Results and discussion. These nootropic agents work by helping to restore balance among the three Doshas , especially by calming Vata, Pitta and Kapha which play an important role in mental functions. They also support brain health by improving communication between neurons and aiding in the repair and nourishment of nerve tissues. These herbs act as natural antioxidants, protecting brain cells from damage caused by oxidative stress and helping to maintain overall cognitive function. The ghrita dosage form being lipid soluble molecules, have the capacity to cross the Blood Brain Barrier thus increasing the availability of active principles in the brain of the above mentioned nootropic agents. Conclusion. By integrating traditional wisdom with contemporary research, Medhya Rasayana emerges as a viable, multifaceted strategy for cognitive enhancement and lifestyle disorder management in the modern era.