Secondary Metabolites Isolated from the Genus Psammocinia Sponges: Mapping Their Chemistry and Biological Activities

This review paper covers publications from 2013 to July 2025, and describes brominated and non-brominated indole alkaloids, ircinianins, terpenoids, and polyketide compound classes from the marine sponge of the genus Psammocinia. It provides an overview of the reported secondary metabolites, their source organisms, geographic origins, and associated biological activities. Also, the structure-activity relationship study and biosynthetic pathways of the reported compounds are illustrated. Herein, 15 new secondary metabolites, including 11 terpenoids and four akaloids, were identified in the Psammocinia sponge species during this period. Briefly, the biological activities of these secondary metabolites involve molecular, cellular, and microbial targets.