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Abstract This article examines the ethics of artificial intelligence (AI)-mediated conflict beyond Earth by connecting debates on autonomous weapons, space ethics, bioethics, and feminist and decolonial theory. It advances a skeptical thesis: In outer space, AI does not simply extend human control over warfighting environments but exposes and deepens structural limits to control under conditions of distance, opacity, and irreversibility. This article argues that hopes for algorithmic mastery of orbital and cislunar battlespaces sit uneasily with the fragility of complex socio-technical systems and with the dual-use dependence of civilian life on space infrastructures. Feminist and decolonial perspectives reveal how AI-enabled space militarization tends to reproduce existing patterns of militarism, hierarchy, and exclusion rather than inaugurate a morally improved off-world future. Against longtermist narratives that portray AI-supported space projects as existential insurance for humanity, the article develops an ethics of restraint and responsibility, grounded in space bioethics and the philosophy of technology, and defends a precautionary stance toward highly autonomous weapon systems in extraterrestrial environments.