SuFEx-Functionalized Pyrroles via Regioselective 1,3-Dipolar Cycloaddition of Münchnones

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Authors

Jayalakshmi Achath · National Institute for Interdisciplinary Science and Technology

Malu Biju · National Institute for Interdisciplinary Science and Technology

Sreejith K. Aravindakshan · National Institute for Interdisciplinary Science and Technology

Jubi John · National Institute for Interdisciplinary Science and Technology

Abstract

We have devised a regioselective synthesis of sulfonyl fluoride-functionalized pyrroles via the 1,3-dipolar cycloaddition of münchnones with 1-bromoethene-1-sulfonyl fluoride. The methodology was scalable and could realize the synthesis of a wide variety of functionalized pyrroles. By subjecting the sulfonyl fluoride-functionalized pyrroles to SuFEx conditions, we could generate interesting pyrrole sulfonamides and sulfonates.

Topics & Keywords

Synthesis and Characterization of Pyrroles Synthesis and Reactivity of Heterocycles Cyclopropane Reaction Mechanisms

Publication Details

Published in: Organic Letters

DOI: 10.1021/acs.orglett.6c01229

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SuFEx-Functionalized Pyrroles via Regioselective 1,3-Dipolar Cycloaddition of Münchnones

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Abstract

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Publication Details