Ophthalmological phenotype associated with biallelic <i>CPAMD8</i> variants: first report in Mexican patients

The literature review revealed that the most frequent manifestations associated with <i>CPAMD8</i> variants are congenital cataract, iris hypoplasia, zonular abnormalities (including phacodonesis and ectopia lentis), and secondary childhood glaucoma (67%). Although the phenotype is heterogeneous, the analysis of <i>CPAMD8</i> should be recommended in patients with anterior segment dysgenesis or secondary childhood glaucoma associated with non acquired ocular anomalies as the aforementioned alterations.