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Introduction:: The present study aimed to formulate and evaluate a liposomal gel con-taining divalproex sodium. Liposomes are currently used as targeted delivery systems. Di-valproex Sodium (DS), the sodium salt of valproic acid (VPA), is a crucial medication primarily employed in the treatment of epilepsy. Valproic acid, with the chemical name sodium 2-propylpentanoate (2-propylpentanoic acid), serves as an anticonvulsant with a molecular weight of 144.211 g/mol and the chemical formula C16H31NaO4. The primary objective of this research was to develop a liposomal gel of divalproex sodium by reducing its particle size for targeted application. Methods:: In this study, liposomes of divalproex sodium were formulated using the solvent evap-oration technique with the addition of phosphatidylcholine and cholesterol. The prepared lipo-somes were characterized on the basis of size, zeta potential, encapsulation efficiency, in vitro release, and pH. Subsequently, a liposomal gel of divalproex sodium was prepared using carbopol 934 (2:1) and characterized for spreadability, viscosity, and in vitro drug release. Results:: The formulated liposomes of divalproex sodium showed an entrapment efficiency of 90.20%, a particle size of 825.7 d.nm, PDI of 0.543, and a zeta potential of -18.7 mV. TEM analysis indicated particle sizes under 20 nm. Subsequently, the liposomal gel of divalproex so-dium was prepared using the gelling agent carbopol 934. The spreadability of the liposomal gel was found to be 5.86 cm, and the % drug release was observed to be 96.6%. The pH study indi-cated that the formulated liposomal gel of divalproex sodium was well stable. discussion: The formulated liposomes of divalproex sodium containing entrapment efficiency (90.20) %, particle size of 825.7d.nm, PDI (0.543) and zeta potential (-18.7 mV) and TEM under 20nm . Afterward the liposomal gel of divalproex sodium were prepared by using gelling agent carbopol 934 and the separability of liposomal gel was found to be (5.86cm) and % Drug release was observed as (96.6%) and the pH study showed that the formulated liposomal gel of divalproex sodium was well stable. Discussion:: The findings demonstrate that the optimized liposomal gel exhibited high entrapment efficiency, controlled drug release, suitable rheological properties, and good spreadability, indi-cating its potential as a stable and effective topical delivery system for DS. Conclusion:: Liposomal formulations containing divalproex sodium were successfully developed using the solvent evaporation technique. Additionally, the liposomal gel containing divalproex sodium was successfully prepared using carbopol 934. Evaluation studies demonstrated that the prepared liposomal gel is stable and suitable for further investigations.