Platelet‐Rich Plasma as a Promising Treatment for Skin Necrosis and Vascular Compromise Following Fat Transfer: A Case Report and Comprehensive Literature Review

ABSTRACT Autologous fat transfer is a widely used technique in aesthetic and reconstructive surgery for volume restoration. Despite its advantages, complications such as vascular compromise and skin necrosis can occur, posing significant challenges. Traditional treatments, including hyaluronidase, hyperbaric oxygen therapy, and corticosteroids, have shown variable success in managing these complications. This study presents a case of a 57‐year‐old woman who developed vascular occlusion and impending skin necrosis following autologous fat transfer. Initial management with deoxycholic acid, betamethasone, and hyaluronidase did not yield significant improvement. The patient was subsequently treated with platelet‐rich plasma (PRP) injections over a 10‐day period, leading to progressive healing, improved skin viability, and prevention of necrosis. Compared with conventional treatments, PRP demonstrated superior regenerative potential by promoting angiogenesis, reducing inflammation, and accelerating tissue repair. A comprehensive literature review supports PRP as an effective intervention for vascular complications post‐fat transfer. PRP offers a novel approach with enhanced aesthetic and functional outcomes, making it a promising alternative to traditional therapies. Further research and large‐scale clinical trials are needed to establish standardized protocols for PRP application in aesthetic medicine.