Successful orthotopic liver transplantation for diffuse hepatic hemangiomatosis in an adult patient

Hepatic hemangioma is the most common benign focal lesion of the liver and is usually small and asymptomatic. However, giant hemangiomas may require surgical intervention, while diffuse hepatic hemangiomatosis with multiple giant hemangiomas is exceedingly rare. We report a rare case of diffuse hepatic hemangiomatosis in a 59-year-old patient complicated by portal hypertension, inferior vena cava syndrome, liver failure, and Kasabach–Merritt syndrome, who successfully underwent orthotopic liver transplantation (LT) from a deceased donor. This case demonstrates the malignant course of a relatively benign disease that required LT. Although giant liver hemangiomas are a rare indication for LT, in selected cases where conservative and surgical treatments are ineffective or contraindicated, transplantation may be a safe and effective therapeutic option.