Albumin-bound nanoparticle (nab) paclitaxel exhibits enhanced paclitaxel tissue distribution and tumor penetration

2015117 citationsJournal Articlehybrid Open Access

Authors

Nianhang Chen

Carrie Baker Brachmann

Xiping Liu · Bristol-Myers Squibb (Switzerland)

Daniel W. Pierce · Bristol-Myers Squibb (Switzerland)

Joyoti Dey · Presage Biosciences (United States)

William Kerwin · Presage Biosciences (United States)

Yan Li · Bristol-Myers Squibb (Switzerland)

Simon Zhou

Abstract

Compared with CrEL-paclitaxel, nab-paclitaxel demonstrated more efficient transport across endothelial cells, greater penetration and cytotoxic induction in xenograft tumors, and enhanced extravascular distribution in patients that are attributed to carrier-mediated transport. These observations are consistent with the distinct clinical efficacy and toxicity profile of nab-paclitaxel.

Topics & Keywords

Nanoparticle-Based Drug Delivery Nanoplatforms for cancer theranostics Angiogenesis and VEGF in Cancer

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Cancer Chemotherapy and Pharmacology

Volume 76, Issue 4, pp. 699-712

DOI: 10.1007/s00280-015-2833-5

Field-Weighted Citation Impact: 4.40