Inside the Neutrophil Phagosome: Oxidants, Myeloperoxidase, and Bacterial Killing

19981,417 citationsJournal Article

Authors

Mark B. Hampton · Christchurch Clinical Studies Trust

Anthony J. Kettle · Christchurch Clinical Studies Trust

Christine C. Winterbourn · Christchurch Clinical Studies Trust

Abstract

IN THE 1880s Elie Metchnikoff observed specialized phagocytic cells ingesting bacteria, and recognized the importance of phagocytosis as a defense mechanism in multicellular organisms.[1][1] Neutrophils are one of the professional phagocytes in humans. They ingest bacteria into intracellular

Topics & Keywords

Neutrophil, Myeloperoxidase and Oxidative Mechanisms Nitric Oxide and Endothelin Effects Neuroinflammation and Neurodegeneration Mechanisms

Publication Details

Published in: Blood

Volume 92, Issue 9, pp. 3007-3017

DOI: 10.1182/blood.v92.9.3007.421k47_3007_3017

Field-Weighted Citation Impact: 9.69

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Inside the Neutrophil Phagosome: Oxidants, Myeloperoxidase, and Bacterial Killing

Authors

Abstract

Topics & Keywords

Publication Details